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Milbemectin

1- Development
2- Physical and Chemical Properties
3- Acute Toxicity
4- Formulations contain this active ingredient
5- Toxicity classification

6- First Aid

7- Exposure Guidelines
Development
Introduced in Japan in 1990 by Sankyo Co., Ltd.
Physical and Chemical Properties
Chemical class

Avermectin

Belong to
List No. I
Chemical structure
Milbemectin chemical structure
CAS RN

[51596-10-2] A3; [51596-11-3] A4

Chemical Abstract Name

A3:(6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B; A4: (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethylmilbemycin B
IUPAC name
A mixture of: (10E,14E,16E,22Z)-(1R,4S,5'S,6R,6'R,8R,13R,20R,21R,24S)-21,24-dihydroxy-5',6',11,13,22-pentamethyl-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6-spiro-2'-tetrahydropyran-2-one and (10E,14E,16E,22Z)-(1R,4S,5'S,6R,6'R,8R,13R,20R,21R,24S)-6'-ethyl-21,24-dihydroxy-5',11,13,22-tetramethyl-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6-spiro-2'-tetrahydropyran-2-one in the ratio 3 to 7
Chemical fomula
A3: C31H44O7; A4: C32H46O7
Form
White, crystalline powder
Melting Point
A3: 212-215 °C; A4: 212-215 °C
Henry's Constant
<9.93  x 10-4 Pa m3 mol-1 (pH 7, 25°C)
Vapour Pressure

A3: <1.3 x 10-5 (in mPa, 20 °C)   A4: <1.3 x 10-5 (in mPa, 20 °C) 

Specific Denisty
A3: 1.1270 (25 °C)  A4: 1.1265 (25 °C)
Solubility
A3: In water 0.88 ppm (20 °C). In methanol 64.8, ethanol 41.9, acetone 66.1, n-hexane 1.4, benzene 143.1, ethyl acetate 69.5 (all in g/l, 20 °C). A4: In water 7.2 ppm (20 °C). In methanol 458.8, ethanol 234.0, acetone 365.3, n-hexane 6.5, benzene 524.2, ethyl acetate 320.4 (all in g/l, 20 °C)
Stability
Unstable to alkali.
Acute toxicity
Oral LD50  mg/kg bwt.
Animal
Male
Female
Rat
762
456
Mice
324
313
rabbite
 
Dermal LD50 mg/kg bwt.
Animal
Male
Female
Rat
>5000
>5000
Gonia big
 
rabbite
Formulations contain this active ingredient
Trade name
registration No
Milbecknok 1% EC 694
Toxicity classification
WHO Classification II

Definition

Moderately hazardous
color code Yellow
First Aid
IF ON SKIN OR CLOTHING:  For gross contamination, immediately drench with water and remove clothing. Continue to flush skin and hair with plenty of water and soap. For skin burns, cover with a clean, dry dressing until medical help is available. If blistering occurs, do NOT break blisters. If swelling, redness, blistering, or irritation occurs seek medical assistance.
IF IN EYES:    If in eyes wash out immediately with water. In all cases of eye contamination it is a sensible precaution to seek medical advice.
IF SWALLOWED: Immediately rinse mouth with water. If swallowed, do NOT induce vomiting. Give a glass of water to drink. Never give anything by the mouth to an unconscious patient. If vomiting occurs give further water. Seek medical advice.
IF INHALED:   Remove victim from exposure - avoid becoming a casualty. Remove contaminated clothing and loosen remaining clothing. Allow patient to assume most comfortable position and keep warm. Keep at rest until fully recovered. If breathing labored and patient cyanotic (blue), ensure airways are clear and have qualified person give oxygen through a facemask. If breathing has stopped apply artificial respiration at once. In the event of cardiac arrest, apply external cardiac massage. Seek immediate medical advice.
 
Exposure Guidelines:
ADI:  0.03 mg/kg/day
RfD:  0.03  mg/kg/day
 
Ministry of AgricultureCAPL
 

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